"It's going to be sore, but I don't think it's anything that's going to be too crazy," Upton said. "I didn't hear any cracks, pops or anything like that."
The injury occurred when Upton raced into the right-field corner to field Eric Sogard's triple in the bottom of the fifth.
"I was trying to cut the ball off, slipped a little and jammed my knee," Upton said.
Upton will be re-examined by the team's training staff on Monday.
"It's a scary thing," D-backs manager Kirk Gibson said of seeing his best offensive player limp off the field. "We don't want to lose him by any means."