The 20-year-old lefty was pounded for seven hits in his three frames, and took his first loss of the spring.
"Coming out of the bullpen is hard for him because he's overthrowing," manager Kirk Gibson said. "They put some good swings on him. It's just important in the Major Leagues that you locate to be successful."
Skaggs was named the organization's 2011 Minor League pitcher of the year, and his presence at big league camp this late in the spring is a testament to his abilities.
His last time out, Skaggs allowed just a run on two hits in three innings, and looked smooth in striking out five. On Saturday, he labored.
But for a youngster like Skaggs to struggle and work through it, Gibson noted, "He probably learned some good lessons out there tonight."