Skaggs replaces Trevor Bauer, who was called up to the big leagues on Thursday, and joins outfielder Alfredo Marte in representing the Arizona organization.
Skaggs, who is pitching for Double-A Mobile, will play on the U.S. Team, while Marte, who also plays for Mobile, will play for the World.
This will be Skaggs' second straight appearance in the game.
"So blessed to be able to go to the [Futures Game] again!" Skaggs tweeted. "Can't wait to get to KC. Another dream come true."