The second baseman was out of the lineup Monday for the first time this year as the D-backs opened a three-game series with the Cubs at Chase Field.
"He's the last guy that's had a day off," manager Bob Melvin said. "Tough guy to give a day off to, but I feel like I need to."
It's not easy to take Lopez out of the lineup because he's been the team's most consistent hitter. The free-agent signee has hit .311 with seven doubles, two homers and a .370 on-base percentage.
"From the very start of Spring Training he's fit in here very well as a person ... very likable guy, a talented guy," Melvin said.
Outfielder Chris Young was in the leadoff spot in Lopez's place. Arizona fans likely remember that Young hit a leadoff homer against Monday's Chicago starter Ted Lilly in Game 2 of the 2007 National League Division Series.
Young also homered against Lilly in the first inning last year at Wrigley Field, though it was not a leadoff one.
Steve Gilbert is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.