Putz, who has been on the disabled list since May 4 with right forearm tightness, threw 24 pitches.
The next step for Putz will be to see how he feels Saturday. If all goes well he will throw another simulated game Monday at Salt River Fields and then the team would like to get him in back-to-back games somewhere Thursday and Friday.
"We expect he will be fine, but you never know," D-backs manager Kirk Gibson said. "His fastball command is what you're interested in. I thought he got a little tired at the end, but overall, for first time on the mound, I thought he did pretty good."
Putz worked up quite a sweat with the roof open, the sun shining brightly and triple-digit temperatures.
"The main thing is you get good and loose," Putz joked about the weather. "I'm encouraged by it."
Steve Gilbert is a reporter for MLB.com. Read his blog, Inside the D-backs, and follow him on Twitter @SteveGilbertMLB. This story was not subject to the approval of Major League Baseball or its clubs.