The first baseman said he began to feel some discomfort during batting practice and that it got worse as the game went on.
"I've never had a quad [injury] before so I don't know," LaRoche said. "I'm fortunate to play a position where I don't have to have my legs 100 percent underneath me to be able to get out there, but the way it is right now it would be pretty tough."
Conor Jackson got the start at first in place of LaRoche with Gerardo Parra getting the nod in left field.
LaRoche said he considers his status day-to-day right now.
"As soon as I go to move or run at all is when it starts to bother me," he said. "As long as I can get around at first it doesn't have to be perfect. I'm not that worried about it, I just don't want it to turn into something more than it is right now."
Since starting the year 0-for-13, LaRoche has gone 8-for-17.