Reynolds has been bothered by a sore right quadriceps muscle since he overextended on a swing during Spring Training.
Because the D-backs have a scheduled day off Thursday, by not playing Wednesday, Reynolds can have back-to-back days off to rest the quad.
"He's a tough guy, he'll answer the bell," D-backs manager A.J. Hinch said. "He's been smart about it so far. We'll see if we can knock out some of the soreness the next two days."
Reynolds has earned a reputation in the clubhouse of playing through injury.
"If there wasn't an off day tomorrow I would be in A.J. 's office right now wanting to play," Reynolds said. "I talked to the trainers and they said two days in a row would do it some good."
Though Reynolds has been seen with the quad wrapped through the first two weeks of the season, the first time it looked as though it affected him on the field was Tuesday night when he slowed down rounding second while trying to score from first on Gerardo Parra's double.
Reynolds was tagged out at the plate.
"It wasn't comfortable by any means," Reynolds said of running on that play. "I didn't overextend it because I didn't want to hurt it any further and really be out. I was being pretty cautious. Hitting and fielding is all fine. It's just when I overextend and run it's pretty sore."